Flavonoids from the heartwood of Dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in HT22 cells.

نویسندگان

  • Ren-Bo An
  • Gil-Saeng Jeong
  • Youn-Chul Kim
چکیده

Two flavonoids, 4,2',5'-trihydroxy-4'-methoxychalcone (1) and (2S)-6,7,4'-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Essential oil composition from the seeds of Dalbergia odorifera T. Chen grown in Hainan, China

Introduction Dalbergia (Fabaceae) has a wide distribution, it is native to the tropical regions of Central and South America, Africa, Madagascar and southern Asia. Dalbergia odorifera T. Chen, a semi-deciduous arbor, is indigenous to Hainan, Guangdong and Guangxi Provinces of China. Its timber is high-grade material for furniture and crafts, and the essential oil of heartwood can be precious pe...

متن کامل

Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum.

Phytohemical investigation on the heartwood of Dalbergia odorifera resulted in the isolation of nine flavonoids. Their structures were elucidated as sativanone (1), (3R)-vestitone (2), (3R)-2',3',7-trihydroxy-4'-methoxyisoflavanone (3), (3R)-4'-methoxy-2',3,7-trihydroxyisoflavanone (4), carthamidin (5), liquiritigenin (6), isoliquiritigenin (7), (3R)-vestitol (8), and sulfuretin (9) based on th...

متن کامل

Diverse fungi associated with partial irregular heartwood of Dalbergia odorifera

Dalbergia odorifera T. Chen is a medium-sized evergreen tree that produces purple-brown heartwood called JiangXiang in traditional Chinese medicine, the formation process of which takes several decades. In this study, a standard culture method was used to isolate fungi from the wounded and normal stems of D. odorifera aiming to investigate the difference between the two types of wood. To charac...

متن کامل

Neuroprotective effect of Aronia melanocarpa extract against glutamate-induced oxidative stress in HT22 cells

BACKGROUND Glutamate (an endogenous excitatory neurotransmitter) at high concentrations contributes to the development of neurodegenerative diseases. Aronia melanocarpa (A. melanocarpa) berries contain anthocyanins and have high antioxidant activities. In this study, we evaluated whether A. melanocarpa berries could protect neuronal cells against glutamate-induced oxidative stress. METHOD A. ...

متن کامل

Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells

Objective(s): Neurodegenerative diseases have been associated with glutamatergic dysfunction. Berberine, an isoquinoline alkaloid broadly present in different medicinal herbs, has been reported to have neuroprotective effect. In the present study, the effects of berberine against glutamate-induced oxidative damage and apoptosis were investigated. Materials and Methods: The cultured PC12 and N2a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 56 12  شماره 

صفحات  -

تاریخ انتشار 2008